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As -glucan is known to induce trained immunity, pan vaccines based on -glucan can potentially protect against other infectious agents, such as Mycobacterium tuberculosis (277)

human clinical trials are rare and preliminary

As TSC1/TSC2 is activated by oxidative stress 28 , the tardigrade lacks the signalling components connecting various stresses such as hypoxia, genotoxic stress and oxidative stress, to downregulation of mTORC1

The long-term effects of type 1 diabetes treatment and complications on health-related quality of life: a 23-year follow-up of the Diabetes Control and Complications/Epidemiology of Diabetes Interventions and Complications cohort

Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

Microbiome-induced trained immunity occurs even in invertebrates lacking adaptive immunity through epigenetic priming (Liao et al., 2023