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2025 Feb;638(8051):787-795

Sorafenib downregulates MCL1, increases the level of available Beclin 1, and results in more binding between Beclin 1 and SLC7A11, which inhibits system x c , leading to the accumulation of lipid ROS, and triggers ferroptosis in hepatocellular carcinoma cells [88]

doi:10.1016/j.molcel.2014.12.023

doi: 10.1111/jcmm.17553 14 KanaiY

The transport system consists of three main proteins, the first of which is the enzyme carnitine palmitoyltransferase I (CPTI) present in the mitochondrial outer membrane that complexes with a long-chain acyl-CoA synthetase and the voltage-dependent anion channel, while the second transport component is carnitine:acylcarnitine translocase (CACT), an integral inner membrane protein, which complexes with carnitine palmitoyltransferase II (CPTII) located on the matrix side of the inner membrane

Leukocyte-endothelial adhesion and angiogenesis in tumors