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[6] [3] [10] A mild deficiency may not cause any discernible symptoms, but moderate deficiency can cause various symptoms, such as feeling tired, lightheadedness, headaches, cold intolerance, pale skin, sore tongue, upset stomach, loss of appetite, hair and skin color changes, numbness or tingling (pins and needles) of the fingers and toes, and tinnitus, and vision, cognitive or psychological problems

Depending on the peptide, they can be administered orally, by a subcutaneous injection, or by applying a topical cream

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Even brief exposures accumulate over time

The effectiveness of these administration strategies depends on various factors, including bioavailability, drug formulation, gastrointestinal conditions, and systemic distribution, which, if not optimized, could compromise therapeutic outcomes and limit the antibiotics efficacy against targeted infections (McCarthy and Avent, 2020

Intranasal administration of mesenchymal stem cell secretome reduces hippocampal oxidative stress, neuroinflammation and cell death, improving the behavioral outcome following perinatal asphyxia