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As the systematic review noted: No clinical safety data were found. When the FDA says insufficient evidence, they mean itwe literally do not have the data to know whether chronic BPC-157 use causes problems that emerge years down the road

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A clinical trial of a NOS inhibitor (546C88) was terminated early because of unexpected numbers of deaths in the group that received the drug.70 Thus, caution maybe needed in the use of blanket inhibition of NO, CO, or H 2 S as this may well have unintended consequences

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They concluded that systemic application of BPC-157 did not alter blood circulation in healthy gingiva, and chronic application of the peptide had potent anti-inflammatory effects on periodontal tissues in ligature-induced periodontitis in rats

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