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Science 304 , 16781682 (2004)

Introduction The term oxidative stress (OS) applies when increased amounts of reactive oxygen species (ROS) surpass the antioxidant (AOX) capacity that naturally offers the protective balance (1)

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Incidentally, cognitively preserved patients with AD pathology exhibited higher astrocytic expression of EAAT2 439

Indeed, in one hand, their activation is involved in neuroinflammation which endanger neurons via cytokines overproduction and on the other hand, atrophy and loss of activity leads to reduced neuronal protection ( 2+ oscillations than young ones under purinergic stimulation