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The carnitine pool provides a vital role in this process as the long chain fatty acyl-CoAs are actually unable to enter the inner mitochondrial matrix due to their large size

1821 This dispelled initial concerns about the inferiority of oral ALA suggested by the findings of an RCT comparing induction therapy with IV ALA followed by oral ALA (1200 mg/day or 600 mg/day)

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Mol Genet Metab 116:107112 Longo N, Amat di San Filippo C, Pasquali M (2006) Disorders of carnitine transport and the carnitine cycle

Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D (2008) Hypothalamic IKK/NF-B and ER stress link overnutrition to energy imbalance and obesity