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These sustainably released itaconate under the acidic environment of lysosomes and exerted excellent anti-inflammatory and antioxidative stress damage in vitro and in vivo for mono-iodoacetic acid-induced OA mice therapy (analyzed by ELISA, H&E staining, and O-fast green staining)
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10.1152/ajpcell.00543.2008 125 MinettiM.PietraforteD.StrafaceE.MetereA.MatarreseP.MalorniW

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