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Through this, LDL binds LDL receptors (LDLRs) on the plasma membrane to be stored as lipid droplets in the cytoplasm, thus decreasing the concentration of circulating LDL [8]

As this is a narrative review, our research team systematically classified and hierarchically sorted out the relevant literature by research topic and evidence type, mainly describing MASLD-CVD pathophysiological mechanism, AI for clinical risk stratification, AI for medical imaging analysis, multimodal AI for cross-organ screening, multi-omics AI for biomarker and mechanism exploration, and AI model challenges and future directions etc

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To generate the ARX-Mut construct, a 14-bp sequence at the ATF4 binding site within the ARX promoter was deleted, introducing a frameshift mutation