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The increased oxidative environment resulting from NOX activity and mtROS production leads to GSH depletion

Chem Ind Chem Eng Q 21(3):399409 Deirmenciolu N, Yldz E, Sahan Y, Gldas M, Grbz O (2021) Impact of tea leaves types on antioxidant properties and bioaccessibility of kombucha

Therefore, depletion of NADPH stores in G6PD-d has the potential to both limit the production of ROS by NOX family enzymes, while simultaneously expediting the accumulation of ROS from non-NADPH-dependent sources, such as the mitochondrial electron transport chain, peroxisomal -oxidation, oxidative protein folding, and other cytoplasmic enzymes (xanthine oxidase, cyclooxygenase, lipoxygenase) 95,96

Although trends in ddit4 , foxo1 , pnp , ppar expression levels were unclear, qRT-PCR and RNA-Seq revealed consistent changes (Figure 6)

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In addition, DDCs alter the components' PK