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Also, despite the presence of major structural and functional abnormalities of brain vessels in Notch3 KO mice neither overt brain lesions nor clinical manifestations have been reported in these mice, a finding which is in striking contrast with the extreme severity of the human disease (236)

ROS overproduction inhibits antioxidant production, leading to further oxidative damage in NAFLD (201)

Lada A, Rudel L, St Clair R