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Some pharmaceutical medications may increase the need for ALC, including AZT, certain antibiotics, isotretinoin, and some anti-seizure medications (carbamazepine, phenobarbital, phenytoin, and valproic acid)

EGCG has been reported to exert its inhibitory effect on platelet viability through several mechanisms: the inhibition of collagen-mediated phospholipase (PL) Cgamma2, blockade of protein tyrosine phosphorylation, and the enhancement of Ca 2(+) -ATPase activity, thereby reducing platelet aggregation and alleviating atherothrombosis (140)

Growth hormone stimulates protein synthesis and reduces the breakdown of protein

77 In contrast, endothelial dysfunctionan early and independent predictor of cardiovascular eventscontributes to both macrovascular and microvascular pathology, playing a central role in the progression of diabetic CVD 78,79 (Fig