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Description
The SLN were prepared by solvent injection method
It acts as a dual agonist at amylin receptors (AMY1R, AMY2R, AMY3R, formed by calcitonin receptor heterodimerized with RAMP1-3) and calcitonin receptors, with structural modifications (e.g., N-terminal fatty acid acylation, proline substitutions) preventing fibril formation, enhancing stability, and enabling once-weekly dosing via albumin binding for prolonged circulation
PBMCs were resuspended to 2 10 6 cells per ml in Roswell Park Memorial Institute (RPMI) 1640 medium with l-glutamine (cat
& Lu, V
E.ToubiaJ.et al
Do not allow the vials to freeze
