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One major outstanding question is why ferroptosis exists, and whether it is adaptive or indicative of a biochemical failure in cells
Additional breakthrough came with the simultaneous discovery of 5-hydroxymethylcytosine (5hmC) and Ten eleven translocation (TET) proteins that oxidize 5 mC into 5hmC using reduced iron (Fe2+) and -ketoglutarate (-KG) as cofactors (Figure 1) (Tahiliani et al., 2009)
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Consequently, an exhaustive examination of mitochondrial function and energy regulation mechanisms will establish the theoretical foundation for targeting mitochondria in cancer treatment
