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Moreover, NAC is a promising bioactive substance for various diseases, such as gastrointestinal inflammation, cardiac injury, acute respiratory distress syndrome, bronchitis, AIDS, nephropathy, and psychiatric disorders 15

Additional conditions under the umbrella of congenital IGF-1 deficiencies include a documented case of a 15-year-old boy suffering from severe prenatal and postnatal growth failure, sensorineural deafness and mental retardation due to a homozygous partial deletion of the IGF-I gene [41] as well as IGF1R genes defects [42]

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