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Landmark trials, including the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) and Irbesartan Diabetic Nephropathy Trial (IDNT) studies, demonstrated that ARBs reduce progression to end-stage kidney disease (ESKD) in type 2 diabetes mellitus (T2DM) patients with proteinuria (112)

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[25] found that knock-out of plasma GPX, GPX-3, resulted in increased platelet-dependent thrombosis in murine models

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G.MatsacosD.SimP.CluneE.MustafaT.et al (2001)
