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Peer review Peer review information Nature Reviews Cardiology thanks Sabzali Javadov, Andreas Linkermann and Eikan Mishima for their contribution to the peer review of this work

Researchers have genetically engineered insulin fusion proteins capable of targeting hippocampal neurons

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Similarly, interference with NADPH oxidases, the primary ROS-generating enzymes, and mitogen-activated protein kinases (MAPKs), key mediators of ROS signaling, leads to cytoskeletal disorganization, emphasizing the critical requirement of redox balance during cell division (Mhamdi and Van Breusegem, 2018)

doi: 10.3389/fimmu.2018.02061 162 LevringT

A critical obstacle in the development of CNS therapies is the bloodbrain barrier (BBB), initially identified by Paul Ehrlich in the late 19th and early 20th centuries