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When they detect unsafe conditions, our mitochondria dial back on energy production and send out danger signalsthis is the cell danger response (CDR)

As a matter of fact, silymarin, a complex of flavonolignans from the fruit Sylibum marianum , has shown in preclinical test to inhibit cholesterol acyltransferase and HMGCoA reductase activity and improve LDLC uptake by the liver, definitely reducing cholesterol absorption and lipoprotein biosynthesis (Skottov & Krecman, 1998

doi: 10.3390/molecules26072090

Common checks include serum/plasma zinc, serum copper, and ceruloplasmin (for copper status)

Therefore, it is suggested that we can refer to these relevant mechanisms in the future research of CM on treating liver diseases

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