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5-Amino-1MQ is a small molecule membrane-permeable inhibitor of the enzyme Nicotinamide N-methyltransferase (NNMT)

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At the cellular level, 5-amino-1MQ orchestrates a complex rebalancing of fundamental metabolic processes through its effects on the NAD+ salvage pathway and one-carbon metabolism

Methods: Authors used a computer-based gene profiling tool, The Connectivity Map, to identify a number of human genes regulated by GHK, relevant to regulation of cell differentiation, apoptosis and stem cell function

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