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Tawfik A, Elsherbiny NM, Zaidi Y, Rajpurohit P

Drug Targets 5 , 251261 (2006)

M.HerreraF.Gomez-ManzanoC.FueyoJ.Alvarez-VegaM

Dysplastic naevi with moderate to severe histological dysplasia: a risk factor for melanoma

1.2 Biochemical mechanisms of TMA production Most of the TMA is synthesized in the intestine (colon) by the action of some anaerobic commensal gut bacteria containing choline- (or carnitine-) TMA lyase, an enzyme consisting of two units: a catalytic unit (CutC) and its activating enzyme (CutD) ( etc .), betaine, and L-carnitine and its metabolite -butyrobetaine (GBB), releasing TMA after the cleavage of the carbon (C)nitrogen (N) bond of choline/carnitine (Zhu et al., 2014)

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