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Carrillo I, Rabelo RAN, Barbosa C, Rates M, Fuentes-Retamal S, Gonzlez-Herrera F, et al
31 Researchers have demonstrated that disorganizing the nucleotides of the seed region without changing the 2-OMe, 2-F or PS content or placing a GNA at position 7 of the siRNA antisense strand can markedly alleviate off-target effects and mitigate hepatotoxicity because these modifications affect the binding of siRNA with undesired target mRNA in a seed region-specific manner
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10.1093/eurheartj/ehx188 150
