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It is preset in mitochondrial respiratory chains and servs to control reactive oxygen species production via electron transport cycling processes such as oxidative phosphorylation

18,19 Mechanism-based inhibitors have been developed and uncovered for GS, including methionine sulfoximine, phosphinothricin (a current herbicide), and tabtoxinine--lactam

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it can also be achieved by activating the Nrf2ARE pathway through controlled lifestyle-related stressors (e.g., exercise, caloric restriction, thermal stress) and specific phytochemicals