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Description
Author Contributions Conceptualization: LI, KEW, NWS Methodology: LI, KEW, NWS Formal Analysis: LI, ST, CD, TM, NK, AF Investigation: LI, ST, CD, JD, TM, NK, AF, PN, LR, JS, HA, AC Visualization: LI Supervision: KEW, NWS, BC, AA Writing - original draft: LI, KEW Writing - review & editing: LI, KEW, NWS, ST, AC, BC, AA, CD, JD, TM, NK, AF, PN, LR, JS, HA Competing Interests No competing interests declared Data and Material Availability All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials

Sympathetic overactivity may further disturb neurovascular balance by favoring vasoconstrictive signaling and reducing the effectiveness of parasympathetic pro-erectile pathways (146)

Early recognition and appropriate management of side effects can often allow continued treatment with dose adjustments or supportive measures rather than requiring discontinuation of therapy

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Sadowski A, et al
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