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The ECM can be cleaved by different families of proteases

1013 Three randomised controlled trials (RCT) have measured the effect of vitamin B 12 supplementation on neurodevelopment in children: In a Norwegian trial, an intramuscular injection of B 12 substantially improved the motor development in 6-week-old infants after 1 month, 14 another intervention study in low birthweight children recently confirmed these findings

A 1% SDS solution was applied to a 1-cm 2 sterile piece of gauze secured to the hair-free back skin with a bio-occlusive dressing (Tegaderm)

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The primary outcome measure was safety, and key secondary outcomes were mean change from baseline best- corrected visual acuity (BCVA), mean change from baseline macular sensitivity measured by microperimetry, change from baseline in ellipsoid zone width at weeks 12 and 24, and NAC levels in the aqueous humor and in plasma