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Drug-induced mitochondrial toxicity

Interestingly, -ketoglutarate can be converted into glutamate, another metabolic intermediate and a neurotransmitter, by mitochondrial glutamate dehydrogenase in the GI tract

Isobaric mass tags Chemical tags that are isobaric (that is, have identical masses), but during tandem mass spectrometry they fragment into reporter ions of different masses

This gentle approach helps you spot side effects early and gives your system time to adjust

3a and Supplementary Table 1), the analysis revealed that the mtDNA copy number relative to nuclear DNA was higher in WT muscle (~939) compared to Alix / (~860) and ccOzz / muscle (~849)