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Ocular complications, including ectopia lentis, myopia, astigmatism, glaucoma and blindness, are the earliest and most common manifestations, affecting 90% of poorly managed individuals (1317)

Other study showed that alanine metabolism can compensate for the intermediates of the TCA cycle and the metabolic derivatives during glutamine deprivation to maintain cell growth and survival (61)

We anticipate that the combination of these tools to integrate omic data will allow the identification of new potential targets to develop future therapies, even though inferring causality will be challenging due to the current gap between in silico predictions, in vivo spurious co-occurrence correlations and cause-effect relationships

In addition to mitophagy, LRRK2 is also involved in other mitochondrial quality control pathways like fusion and fission and its cytoskeleton dynamics and trafficking (Singh et al., 2019)

Dameron C.T., Harrison M.D

doi: 10.1038/s41419-017-0089-1