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[DOI] [PMC free article] [PubMed] [Google Scholar] 226.Brown R
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The overexpression of preadipocyte factor-1 (Pref-1), a secreted protein that inhibits adipocyte differentiation, also induced the characteristics of lipodystrophic models, that is, reduced adipose tissue mass, dyslipidemia, and insulin resistance [97,98]
doi:10.1038/d41586-019-02667-5
For medications that are used off-label we can only provide guidelines and safety information for use
The evidence base is preclinical with one small human study
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