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Apo M as a chaperone of sphingosine-1-phosphate (S1P) contributes to the formation of Apo M/S1P complex in HDL, which interacts with S1P receptors (S1PR) to promote vascular barrier function and exert antiinflammatory functions 90,91

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Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents

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