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[PMC free article] [PubMed] [Google Scholar] 152.Ibitoye R., Kemp K., Rice C., Hares K., Scolding N., Wilkins A

Apoptosis is a natural process by which damaged or abnormal cells are eliminated, and its impairment is a hallmark of cancer

10.1186/s13048-015-0140-8 43

This lactate shuttle not only fuels mitochondrial metabolism in cancer cells but also contributes to acidification of the extracellular environment, which promotes invasion, immune evasion, and angiogenesis (131, 136)

The L mRNA is expressed in liver and white adipose tissue, the M mRNA is expressed in skeletal muscle and white adipose tissue, and the F mRNA is expressed in fibroblasts, proliferating cells, and fetal tissues

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