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6/8/2020 Topiramate (Topamax) tablets and sprinkle capsules FDA approved a supplemental new drug application from Janssen Pharmaceuticals that provides for the addition of serious skin reaction, Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), to the Warnings and Precautions and Patient Counseling Information sections of the Prescribing Information (PI) and to the Medication Guide

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In essence, LL-37 converts normally non-immunogenic self-DNA into a powerful trigger for autoimmune activation

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However, gastrointestinal ulceration is still poorly understood, particularly with respect to a general pharmacological/pathophysiological role of various angiogenic growth factors implemented in growth factors wound healing concept

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