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Absence of expected improvement by mid-protocol (4-6 weeks) warrants reassessment

Clinical isolates show considerable genomic diversity, including chromosomal duplications and non-classical mutations, complicating treatment strategies (Priest et al., 2022

unlike single-form or cyanocobalamin products, this dual-form combination provides complete bioactive coverage

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It is generally agreed that we have no evidence that febuxostat is a negative for the heart, just the question of the CARES trial as to whether it is not as protective as allopurinol

it is safe and effective to provide additional SLT treatment to previously treated TM, with retreatment providing similar IOP reduction as primary SLT