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Ductal epithelial cells can recognize pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) through Toll-like receptors (TLRs) (15, 41), which, upon activation, can promote the secretion of type I interferons and B-cell activating factor (BAFF), induce apoptosis, and release self-antigens (4245)

Additionally, inflammatory signals and the overload in intracellular calcium ion could be also implicated in this complex network that has not yet been elucidated

Grapefruit juice is perhaps the most well-known food inhibitor of this enzyme [74], though resveratrol and garden cress, a member of the cruciferous vegetable family, appear to have similar effects in humans, albeit at intakes above what would be expected without high-dose supplementation [28, 55]

FADS2, Fatty Acid Desaturase 2

Folic acid, a synthetic form of folate, is found in fortified foods and dietary supplements

The increase of the pro-inflammatory cytokine tumor necrosis factor (TNF), caused by reduced melatonin production is considered as biomarker of AD progression [109]