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Numerous regulators promoting the NLRP3 inflammasome formation and activation have been identified, such as MyD88 and TRIF contributing to the priming of the NLRP3 inflammasome, 172 caspase-8, and FADD (Fas-associated death domain protein) to mediate the priming and activation of the canonical and noncanonical NLRP3 inflammasome

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