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Acknowledgments The authors would like to thank the National Council for Scientific and Technological Development (CNPq) (Grant: 448905/2014-0 to A.A.S.R.)

1:20,000/ anti-rabbit IR-Dye800

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Secondly, targeting ferroptosis may enhance treatment efficacy and improve patient outcomes [278, 311]

However, the precise orchestra of protective mechanisms, including antioxidant capacity, might vary with species based on their life history traits, with age and with sex

Evidence has been presented for the nature of this labile iron pool as being iron(II)glutathione (Hider and Kong 2011), GSH acting as a buffer for iron(II), maintaining iron in the reduced state