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RT-qPCR analysis confirmed the activation of inflammatory and immune responses, evidencing upregulation of Nod1 ( NOD-like receptor 1 ), Tlr-2, Tlr-4, Tlr-6 ( Toll-like receptor-2, 4, 6 ), Nlrp3 ( NLR family pyrin domain containing 3 ), Il-1 ( Interleukin-1 ) and Ifn- ( Interferon- ) and downregulation of Ikb- ( NF-kappa-B inhibitor alpha ) and Reg3- ( Regenerating islet-derived protein 3- )

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SIRT1 is pivotal as it catalyzes lysine residue acetylation on histone substrates and non-histone proteins, controlling gene expression [38]

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Small-Howard AL, Berry MJ

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