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Another key neurotrophic factor, glial cell line-derived neurotrophic factor (GDNF), has demonstrated significant neuroprotective effects in preclinical models of PD

704 Another antioxidant, resveratrol, also inhibits iron accumulation and lipid peroxide production by activating the Nrf2/GPX4 signaling pathway, thereby inhibiting neuronal ferroptosis and promoting the recovery of motor function in mice

Frontal cortex concentrations increased by 50% from 2016 to 2024, with dementia cases exhibiting higher accumulation than controls (Nihart et al., 2025)

Inositol phosphate kinases: expanding the biological significance of the universal core of the protein kinase fold