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(16) As a result, some (but not all) folate conjugates are released from their receptors when the compartments of the endosome are acidified to a pH of 5 after the formation of an endocytic vesicle following the invagination of the membrane and internalization

Funding This research was funded by Innovation Team Project of Dalian Ocean University, China (B202102) and the Central Guidance on Local Science and Technology Development Fund of Hebei Province (226Z7103G), China

Within experimental models, it is commonly investigated for its interaction with peptide-mediated signalling networks and molecular mechanisms