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Dihydrofolate reductase is a key enzyme in folate metabolism in vivo, responsible for the reduction of dihydrofolate to tetrahydrofolate, which is involved in the methyl shuttle required for the ab initio synthesis of thymidylate and certain amino acids

The classic symptoms of holocarboxylase synthetase deficiency are hypotonia, lethargy, seizures, metabolic acidosis, vomiting, hyperammonemia, developmental delay, skin rash, and alopecia

Lifetime TIRF microscopy To determine the effect of mutating the CHC-NTD Clathrin, Arrestin and W-boxes in how endocytosis progresses, cells tagged with Ent1/2p-mNeonGreen, Chc-mScarlet and Abp1-mTurquoise2 were used

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Singer K, Cheng WC, Kreutz M, Ho PC, Siska PJ