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[230] reported that PSO can reduce the abundance of Escherichia-Shigella by increasing the abundance of the dominant bacterial genera Akkermansia muciniphila and Norank_F_Muribaculaceae , as well as by promoting intestinal bile acid metabolism and increasing the expression of certain bile acid transporters, thereby lowering the levels of inflammatory factors (IL-6, IL-1,and TNF-) and affecting the integrity of the intestinal barrier

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Mol Aspects Med 25(56):455473 El-Hattab AW, Scaglia F (2015) Disorders of carnitine biosynthesis and transport

doi: 10.1007/s00394-021-02491-6 [DOI] [PubMed] [Google Scholar] 137

Examples of first generation antiandrogens include bicalutamide, flutamide, and nilutamide, which inhibit androgen action by binding to the androgen receptor in a competitive fashion, ie , as an antagonist