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A medication like liraglutide can alter food preference and reward pathways in the brain by activating the GLP-1 receptor more powerfully over time than the bodys natural hormone, helping address insulin resistance and weight management

With only a single case report, it is however difficult to correlate this phenotype with the loss of function of any of these genes [170]
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Importantly, anti-PCSK9 therapy will decrease circulating LDL cholesterol while increasing the exposure of PCSK9- and LDLR-expressing tissues to LDL cholesterol, perhaps providing a partial explanation for the contradictory anti- and pro- cancer effects of PCSK9 inhibition seen in different tumor models
