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EMBO Rep 8:1074-1079

BBR appears to prolong small intestinal transit time, which may contribute to gastrointestinal side effects

Importantly, much of HDLs (and apoA-Is) inhibition of macrophage activation is mediated through altering cholesterol levels in plasma membrane lipid rafts through cholesterol efflux mediated by ABCG1/SR-BI and ABCA1

The absence of standardized protocols and long-term safety data means that patients must navigate this treatment option with heightened caution and informed consent

This will require additional targeted investigations, including analysis with different hydrolysis protocols, collision energies, and chromatographic conditions to collect more detailed structural information and support the synthesis of chemical standards that will allow absolute identification and quantitation