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As adult neurogenesis is negatively correlated with stress and depression (Zhao et al., 2008) and major depression correlates with increased DNA methylation in the cortex (Veldic et al., 2005), this raises an intriguing possibility: could the depression-linked decrease in adult neurogenesis be a consequence of the increased methylation of NeuroD1 promoter in developing neurons

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doi: 10.1007/s12031-012-9773-x

6 ClinicalTrials.gov REDEFINE 1 (NCT05567796)Registry record for the pivotal phase 3 CagriSema weight-management trial in adults without type 2 diabetes

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