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Available from: Courtiol E, Wilson DA

Shao M, Liang H, Xu G, Zhu J, Li S, Ren M

Contributing to the neural degeneration seen in vitamin B12 deficiency is the reduced synthesis of S-adenosylmethionine (SAM

Furthermore, neuroprotective and disease-modifying agents, including histone deacetylase 6 (HDAC6) inhibitors and metabolic regulators like metformin, show mechanistic promise but face challenges such as poor solubility, rapid clearance, non-specific distribution, and low brain bioavailability 17,18,19,20

doi: 10.1097/HP.0000000000000450

Developmental programming of obesity and metabolic dysfunction: role of prenatal stress and stress biology