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Cell Death Dis 17 , 612 (2026)

10.1016/j.freeradbiomed.2022.10.003 143 SteinmanL

In addition to targeting VEGF/VEGFR signaling, rhamnetin also interferes with the function of HIF-1, a transcription factor that becomes stabilized in hypoxic tumor environments and drives the expression of VEGF and other pro-angiogenic genes

Over time however, the ability of the lens to actively regulate its volume becomes impaired [32] due to oxidative damage to the pathways that regulate fibre cell volume resulting in the localised zone of tissue liquefaction observed in diabetic cortical cataract

[DOI] [PubMed] [Google Scholar] [40].Pocernich CB, La Fontaine M, Butterfield DA

Engelen M et al (2012b) Bezafibrate lowers very long-chain fatty acids in X-linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation