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As a deubiquitinating enzyme, OTUD1 facilitates ferroptosis by IREB2-mediated TRF1 expression in colon cancer cells, which in turn promotes the release of damage-associated molecular patterns (DAMPS) from dying cancer cells, subsequently, DAMPS enhances immune cell activity for killing to cancer cells [91]

10.1016/j.phymed.2019.152954 127 LiX.-x.HeG.-r.MuX.XuB.TianS.YuX.et al (2012)

A stronger immune system reduces the skin damage caused by skin infections

31,32 Four double-blind, placebo-controlled trials evaluated the efficacy of zinc alongside methylphenidate (Ritalin), and found that children in the zinc group improved more than those in the placebo group, 33,34,35,36 although this was not statistically significant in one study

It reduces oxidative damage, decreases viral replication, and strengthens defenses against environmental pollutants

O., Van Laer, L