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It is suggested that phosphorylation impacts on the allosteric regulation of MTHFR via altering the equilibrium of active and inactive states of the enzyme, favoring the inactive state which SAM preferentially binds 21

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At the same time, there are paradoxes: small dogs often produce more ROS yet still accumulate fewer pathologies, while wild canids of comparable size live longer than domestic breeds, suggesting that selective breeding has altered antioxidant capacity