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However, this therapeutic approach also brings side effects, such as -cell hyperplasia and hyperglucagonemia, and the mechanisms underlying these side effects remain elusive

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Most available information comes from clinical trial protocols that don't translate easily to real-world use

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Mast Cells Participate in Chronic Low-Grade Inflammation within Adipose Tissue. Obesity Reviews: An Official Journal of the International Association for the Study of Obesity, vol

This is important for understanding the pathophysiology of gut perfusion disturbances because the areas supplied by mesenteric vessels are compromised early in stress or shock states to preserve heartlung-brain circulation