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These findings align with clinical observations in humans, where biallelic CNTNAP2 variants are linked to severe cognitive impairment, epilepsy, and behavioral abnormalities, underscoring its role in ASD pathogenesis ( The loss of CNTNAP2 leads to synaptic changes in vitro , reduced inhibitory and axonal excitability defects in acute hippocampal slices ( in vivo mPFC local field potential (LFP) oscillations, which may underlie autism-related phenotypes ( There is evidence suggesting that the homeodomain transcription factor Engrailed2 (En2) appears to be a susceptibility locus for ASD ( EN2 is primarily found in postnatal GABAergic neurons in the mouse hippocampus and cortex

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Paul 2022

And, then they just ended up like having these amazing podcasts and being huge influencers, which is the funniest thing ever

Anticonvulsant effect of time-restricted feeding in a pilocarpine-induced seizure model: metabolic and epigenetic implications