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Nemani A, Sankaranarayanan G, Olasky JS, Adra S, Roberts KE, Panait L,

Proudfoot AT, Krenzelok EP, Vale JA

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549 The reactive astrocytes can promote excitotoxic injury of motor neurons by producing nitric oxide and peroxynitrite, which cause mitochondrial damage and apoptosis in cultured neurons, decreasing glutamate transport, releasing pro-apoptotic mediators selectively toxic to motor neurons

For instance, tumor-targeted delivery of RCD inducers via nanocarriers responsive to tumor-specific stimuli can mitigate systemic toxicity while maximizing antitumor efficacy (164)