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After ligand binding, the activated IGF-1 or insulin receptor phosphorylates several intracellular substrates, including IR substrates (IRS) and the Src-homology-2-domain containing transforming protein (Shc)

The NIH's National Institute on Aging (NIA) has a comprehensive list of questions to ask during this process (or any time when deciding whether to join a clinical trial)

F.Molina-DazA.et al
PLoS One 9, e92094 Gavalda, S., Bardou, F., Laval, F., Bon, C
The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity