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Overall these alterations in metabolism pathways resulted in a substantial reduction in the levels of metabolites such as aspartate, asparagine, glutamine, histidine, N-formimino-glutamate, sarcosine, and ethanolamine phosphate in LC patients ( Figure 4B , Supplementary Figure 3B )

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doi: 10.1016/j.jpba.2006.04.002 79 HordieiKGontovaTTrumbeckaiteSYaremenkoMRaudoneL

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This is exemplified by lipid ROS that, in ferroptosis, induce tumor cell death and regulate immune responses by oxidizing tumor signaling lipid and protein (Shi et al

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Ge M., Chen H., Zhu Q., et al., Propofol PostConditioning Alleviates Hepatic Ischaemia Reperfusion Injury via BRG1Mediated Nrf2/HO1 Transcriptional Activation in Human and Mice, Journal of Cellular and Molecular Medicine 21, no

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6a), suggesting similar levels of hypoxia, or in immune, vascular, neuron, astrocyte and oligodendrocyte cell populations (Extended Data Fig

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